Keyword Analysis & Research: cadasil and carasil

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What is the pathophysiology of CARASIL and CADASIL?

CADASIL and CARASIL are hereditary small vessel diseases leading to vascular dementia. CADASIL commonly begins with migraine followed by minor strokes in mid-adulthood. Dominantly inherited CADASIL is caused by mutations (n > 230) in NOTCH3 gene, which encodes Notch3 receptor expressed in vascular smooth muscle cells (VSMC).

What does CADASIL stand for?

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy ( CADASIL) is an autosomal dominant microvasculopathy characterized by recurrent lacunar and subcortical white matter ischemic strokes and vascular dementia in young and middle age patients without known vascular risk factors.

What does CARASIL stand for?

Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), or Maeda syndrome, is characterized by intense arteriolosclerosis without GOM deposition.

Is there a cure for CADASIL or CARASIL?

There is no cure for CADASIL or CARASIL. Treatment for the condition focuses on managing patient symptoms. Migraine headaches and seizures associated with CADASIL may be treated using medications. Patients may be instructed to take aspirin daily to help lower their risk of a heart attack or stroke.

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