Keyword Analysis & Research: htra1


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What is the HTRA1 gene?

Learn more The HTRA1 gene provides instructions for making a protein that is found in many of the body's organs and tissues. This protein is a type of enzyme called a serine protease, which has an active center that cuts (cleaves) other proteins into smaller pieces.

Is HtrA serine peptidase 1 (HTRA1) involved in age-related macular degeneration?

High HTRA1 expression is associated with cervical cell proliferation. Data indicate HtrA serine peptidase 1 (HTRA1) involvement in Age-related macular degeneration (AMD) pathogenesis. Variants in HTRA1 are not associated with age-related macular degeneration.

What are the novel targets of HTRA1?

In addition, two novel targets of HTRA1 have been identified: EFEMP1, an extracellular matrix protein mutated in Doyne honeycomb retinal dystrophy, a genetic eye disease similar to AMD, and thrombospondin 1 (TSP1), an inhibitor of angiogenesis.

What does HTRA3 stand for?

"Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2". Biochem. J. 371 (Pt 1): 39–48. doi: 10.1042/BJ20021569.

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