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Is pemetrexed plus gemcitabine effective for advanced non-small cell lung cancer?

DOI: 10.1200/JCO.2007.15.0375 Abstract Purpose: Cisplatin plus gemcitabine is a standard regimen for first-line treatment of advanced non-small-cell lung cancer (NSCLC). Phase II studies of pemetrexed plus platinum compounds have also shown activity in this setting.

Is pemetrexed better than cisplatin for advanced NSCLC?

This is the first prospective phase III study in NSCLC to show survival differences based on histologic type. In advanced NSCLC, cisplatin/pemetrexed provides similar efficacy with better tolerability and more convenient administration than cisplatin/gemcitabine.

What are the possible side effects of cisplatin/pemetrexed?

For cisplatin/pemetrexed, rates of grade 3 or 4 neutropenia, anemia, and thrombocytopenia (P <or= .001); febrile neutropenia (P = .002); and alopecia (P < .001) were significantly lower, whereas grade 3 or 4 nausea (P = .004) was more common.

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