Keyword Analysis & Research: selleckchem blz945


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What is the IC50 of BLZ945?

BLZ945 is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs. Selleck's BLZ945 has been cited by 19 publications Nat Med, 2019, 25 (12):1839-1842 Cell Stem Cell, 2019, 24 (4):654-669

How does BLZ945 work in bone marrow macrophages?

In bone marrow-derived macrophages (BMDMs), BLZ945 specifically inhibits CSF-1-dependent proliferation with EC50 of 67nM, and decreases CSF-1R phosphorylation. BLZ945 blocks the reciprocal effects between macrophages and glioma cells on the survival, proliferation and/ or polarization of each other to promote tumorigenesis. [1]

How many studies have been cited in selleckchem products?

Since Jan 2010, Selleckchem products have been cited in 415 studies from top scientific journals. Nature, 2021, 10.1038/s41586-021… Nature, 2021, 10.1038/s41586-021… Nature, 2021, 10.1038/s41586-021…

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