Keyword Analysis & Research: selleckchem venetoclax


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Is venetoclax a BCL2 inhibitor?

Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Kiof 0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagyin triple negative breast cancer MDA-MB-231 cells. Phase 3. ABT-737

What is venvenetoclax (ABT-199)?

Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with K i of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Phase 3.

Does venetoclax Induit l'autophagy?

Vénétoclax induit l'autophagie . Venetoclax (ABT-199; GDC-0199) ist ein hochpotenter, selektiver und oral bioverfügbarer Bcl-2 -Inhibitor mit einem K i von weniger als 0,01 nM. Venetoklax induziert autophagy .

What is venvenetoclax used for in breast cancer?

Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3.

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