Keyword Analysis & Research: sufentanil morphine


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How much sufentanil is needed to convert morphine to sufetanil?

When converting morphine to sufentanil in an implanted pump, we, based on the potency ratio of sufentanil to morphine, arbitrarily use a dose conversion of 1 μg of sufentanil to 1000 μg (that is 1 mg of morphine). Animal toxicology studies of IT sufentanil have shown no detectable pathological effects on spinal cord histology.

Is sufentanil the primary analgesic for acute pain in the emergency department?

Sufentanil is an inexpensive synthetic opioid with a high therapeutic index and rapid onset of action, making it an attractive agent for management of acute pain in the ED. Objective: The objective of our study was to evaluate the safety and efficacy of i.n. sufentanil as the primary analgesic for acute pain in the ED.

Why is sufentanil so effective so quickly?

Sufentanil is highly lipid soluble, more so than fentanyl and alfentanil. It rapidly crosses the blood-brain barrier and equilibrates with the CSF and, therefore, has a rapid onset of action. The analgesic effect is terminated quickly as a result of rapid redistribution to fat and skeletal muscle.

What is the intranasal route of sufentanil administration?

The intranasal (i.n.) route provides a safe, effective, and painless alternative method of drug administration. Sufentanil is an inexpensive synthetic opioid with a high therapeutic index and rapid onset of action, making it an attractive agent for management of acute pain in the ED.

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