Keyword Analysis & Research: sufentanil vs morphine

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Does sufentanil have a higher therapeutic index than morphine?

The therapeutic index of sufentanil was markedly higher (26716) than those of morphine (71) and fentanyl (277) in preclinical models; this factor has clinical significance due to the lower incidence of respiratory depression with sufentanil than that with the other opioids 4, 16.

What is the difference between fentanyl and sufentanil?

Sufentanil, like fentanyl, has no active metabolites. It is 5-10 times more potent than its parent drug fentanyl 5, 19.

What is the difference between fentanyl and morphine?

One of the main differences between the two is that fentanyl is a synthetic opioid and morphine is a pure opiate derived from the opium poppy plant. As a class of drugs, opioids encompass both man-made opioid drugs and all opiate drugs that are derived from opium.

Is sufentanil the primary analgesic for acute pain in the emergency department?

Sufentanil is an inexpensive synthetic opioid with a high therapeutic index and rapid onset of action, making it an attractive agent for management of acute pain in the ED. Objective: The objective of our study was to evaluate the safety and efficacy of i.n. sufentanil as the primary analgesic for acute pain in the ED.

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