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What does Vps35 stand for?

VPS35 (VPS35 Retromer Complex Component) is a Protein Coding gene. Diseases associated with VPS35 include Parkinson Disease 17 and Hereditary Late-Onset Parkinson Disease . Among its related pathways are Signaling by GPCR and Signaling by Wnt .

What is the function of vps35-vps26 and Vps29?

The VPS35-VPS26-VPS29 trimer forms the cargo recognition complex of the retromer. Vacuolar protein sorting ortholog 35 (VPS35) is a protein involved in autophagy and is implicated in neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease (AD).

Where is Vps35 transcribed in humans?

In humans, VPS35 is transcribed on chromosome 16q11.2 where is spans about 29.6 kilobases and contains 17 exons. It is evolutionarily conserved and required for survival, as mouse knockout studies have demonstrated embryonic lethality.

What diseases are associated with the VPS35 gene?

Diseases associated with VPS35 include Parkinson Disease 17 and Hereditary Late-Onset Parkinson Disease . Among its related pathways are Signaling by GPCR and Signaling by Wnt . Gene Ontology (GO) annotations related to this gene include binding and obsolete protein transporter activity .

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