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What does Vps35 stand for?

Vacuolar protein sorting ortholog 35 (VPS35) is a protein involved in autophagy and is implicated in neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease (AD).

What is the function of vps35-vps26 and Vps29?

The VPS35-VPS26-VPS29 trimer forms the cargo recognition complex of the retromer. Vacuolar protein sorting ortholog 35 (VPS35) is a protein involved in autophagy and is implicated in neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease (AD).

What is Vps35 in Alzheimer’s disease?

The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking. Deficiency in VPS35 by altering APP/Aβ metabolism has been linked to late-onset Alzheimer’s disease.

What is the difference between exvps35 and envps35?

In (B), exVps35 represents exogenous Vps35, whereas enVps35 stands for endogenous Vps35. Neither ectopic Vps35 nor Vps35D620N affected overall expression levels of endogenous Vps35 or Tetherin.

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