Keyword Analysis & Research: vps35 alzheimers


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Is deficiency in Vps35 linked to Alzheimer’s disease?

Deficiency in VPS35 by altering APP/Aβ metabolism has been linked to late-onset Alzheimer’s disease. Here we report that VPS35 is significantly reduced in Progressive Supra-nuclear Palsy and Picks’ disease, two distinct primary tauopathies.

What does Vps35 stand for?

[…] The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking. Deficiency in VPS35 by altering APP/Aβ metabolism has been linked to late-onset Alzheimer’s disease.

What is the function of the vvps35 protein?

VPS35 is the major component of the recognition core of the retromer complex system, which normally controls transport and sorting pathways for several cargo proteins out of the endosomes. It is the single most critical protein of the whole retromer assembly since knocking it down is sufficient to cause dysfunction of the entire complex.

Is Vps35 involved in Progressive supra-nuclear palsy?

Here we report that VPS35 is significantly reduced in Progressive Supra-nuclear Palsy and Picks’ disease, two distinct primary tauopathies. In vitro studies show that overexpression of VPS35 leads to a reduction of pathological tau in neuronal cells, whereas genetic silencing of VPS35 results in its accumulation.

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