Keyword Analysis & Research: vps35 autophagy

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What is the function of the vvps35 gene?

VPS35 is defined as an autophagy-related encoding gene owing to as a subunit of retromer participating in the regulation of autophagy process. The retromer is able to sustain lysosome structure stability and normal lysosome function, which participates in regulating autophagy process [28].

What is the function of vps35-vps26 and Vps29?

The VPS35-VPS26-VPS29 trimer forms the cargo recognition complex of the retromer. Vacuolar protein sorting ortholog 35 (VPS35) is a protein involved in autophagy and is implicated in neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease (AD).

Is Vps35 an oncogenic factor in breast cancer?

VPS35 is a necessary element for autophagy completion and also promotes breast cancer cell proliferation, migration and invasion. Hence, VPS35 may serve as a promising novel oncogenic factor, prognostic biomarker and therapeutic target for breast cancer.

Is a vps35-based approach an effective treatment for Parkinson's disease?

"VPS35-Based Approach: A Potential Innovative Treatment in Parkinson's Disease". Frontiers in Neurology. 10: 1272. doi: 10.3389/fneur.2019.01272. PMC 6928206. PMID 31920908. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. ^ "Mouse PubMed Reference:".

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