After translation, VPS35 localizes to the endosome, where it, along with the retromer, has been studied in various phagocytotic processes. Sortilin and the cation-independent mannose-6-phosphate receptor ( CI-MPR) regulate lysosome-mediated degradation and are known VPS35 cargo-proteins.What does Vps35 stand for?
Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene encoding a core component of the retromer complex, have recently emerged as a new cause of late-onset, autosomal dominant familial Parkinson's disease (PD).What is the function of vps35-vps26 and Vps29?
The VPS35-VPS26-VPS29 trimer forms the cargo recognition complex of the retromer. Vacuolar protein sorting ortholog 35 (VPS35) is a protein involved in autophagy and is implicated in neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease (AD).What is the isoelectric point of a Vps35 protein?
VPS35 was first identified in Saccharomyces cerevisiae from a study investigating the formation of lysosome-like vacuoles and sorting of vacuolar proteins. The protein contains 796 amino acid residues, with a molecular mass of 92 kDa and an isoelectric point of 5.32.