Keyword Analysis & Research: vps35 mass

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What is the function of Vps35?

The VPS35 protein is a component of the retromer complex and participates in the recycling of membrane proteins via retrograde transport from endosomes back to the trans-Golgi network ( Bonifacino and Hurley, 2008 ).

What is the isoelectric point of a Vps35 protein?

VPS35 was first identified in Saccharomyces cerevisiae from a study investigating the formation of lysosome-like vacuoles and sorting of vacuolar proteins. The protein contains 796 amino acid residues, with a molecular mass of 92 kDa and an isoelectric point of 5.32.

Where is Vps35 transcribed in humans?

In humans, VPS35 is transcribed on chromosome 16q11.2 where is spans about 29.6 kilobases and contains 17 exons. It is evolutionarily conserved and required for survival, as mouse knockout studies have demonstrated embryonic lethality.

What is the role of Vps35 in the treatment of tauopathy?

"VPS35 regulates tau phosphorylation and neuropathology in tauopathy". Molecular Psychiatry. doi: 10.1038/s41380-019-0453-x. PMC 6949432. PMID 31289348. ^ a b c d e f g h i j k l m n Rahman AA, Morrison BE (March 2019).

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