Keyword Analysis & Research: vps35 protein

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What is the function of Vps35?

The VPS35 protein is a component of the retromer complex and participates in the recycling of membrane proteins via retrograde transport from endosomes back to the trans-Golgi network ( Bonifacino and Hurley, 2008 ).

What is the isoelectric point of a Vps35 protein?

VPS35 was first identified in Saccharomyces cerevisiae from a study investigating the formation of lysosome-like vacuoles and sorting of vacuolar proteins. The protein contains 796 amino acid residues, with a molecular mass of 92 kDa and an isoelectric point of 5.32.

What diseases are associated with the VPS35 gene?

Diseases associated with VPS35 include Parkinson Disease 17 and Hereditary Late-Onset Parkinson Disease . Among its related pathways are Signaling by GPCR and Signaling by Wnt . Gene Ontology (GO) annotations related to this gene include binding and obsolete protein transporter activity .

Is Vacuolar protein sorting-associated protein 35 upregulated in breast cancer?

We also clarified that vacuolar protein sorting-associated protein 35 (VPS35), one of ARGs in the risk model, was upregulated in breast cancer samples and cell lines. VPS35 overexpression was correlated with more aggressive phenotype of breast cancer and indicated worse prognosis in both progression-free survival and overall survival analyses.

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