Keyword Analysis & Research: vps35a

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What is the function of Vps35?

The VPS35 protein is a component of the retromer complex and participates in the recycling of membrane proteins via retrograde transport from endosomes back to the trans-Golgi network ( Bonifacino and Hurley, 2008 ).

What is the isoelectric point of a Vps35 protein?

VPS35 was first identified in Saccharomyces cerevisiae from a study investigating the formation of lysosome-like vacuoles and sorting of vacuolar proteins. The protein contains 796 amino acid residues, with a molecular mass of 92 kDa and an isoelectric point of 5.32.

What diseases are associated with the VPS35 gene?

Diseases associated with VPS35 include Parkinson Disease 17 and Hereditary Late-Onset Parkinson Disease . Among its related pathways are Signaling by GPCR and Signaling by Wnt . Gene Ontology (GO) annotations related to this gene include binding and obsolete protein transporter activity .

Does vps41 associate with rabg3f in Vps35?

Also, VPS41 remained associated to RABG3f in the presence of ES17, indicating a VPS35 independent interaction, unlike the recruitment of VPS33 and VPS39. This information indicates that VPS41 associates to RAB7 homologs that later become activated and bind VPS35, suggesting a partial order of assembly.

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