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The VPS35 protein is a component of the retromer complex and participates in the recycling of membrane proteins via retrograde transport from endosomes back to the trans-Golgi network ( Bonifacino and Hurley, 2008 ).What is the isoelectric point of a Vps35 protein?
VPS35 was first identified in Saccharomyces cerevisiae from a study investigating the formation of lysosome-like vacuoles and sorting of vacuolar proteins. The protein contains 796 amino acid residues, with a molecular mass of 92 kDa and an isoelectric point of 5.32.What diseases are associated with the VPS35 gene?
Diseases associated with VPS35 include Parkinson Disease 17 and Hereditary Late-Onset Parkinson Disease . Among its related pathways are Signaling by GPCR and Signaling by Wnt . Gene Ontology (GO) annotations related to this gene include binding and obsolete protein transporter activity .Does vps41 associate with rabg3f in Vps35?
Also, VPS41 remained associated to RABG3f in the presence of ES17, indicating a VPS35 independent interaction, unlike the recruitment of VPS33 and VPS39. This information indicates that VPS41 associates to RAB7 homologs that later become activated and bind VPS35, suggesting a partial order of assembly.